FAQ
Frequently Asked Questions
- Is the ADE and PDE the same?
- In reviewing the OEL and ADE equations, I see that the lowest therapeutic dose was used as the point of departure rather than the NOEL (no observed effect level) or NOAEL (no observed adverse effect level)
- Does the occupational exposure limit (OEL) or acceptable daily exposure (ADE) value change based on the formulation?
- How does Affygility Solutions determine the OEL and/or ADE?
- Occupational Health Category vs. Occupational Exposure Limit
- Is there a relationship between a LD50 and an ADE
- Is there a way to estimate the acceptable surface limit from the ADE?
- What is a CAS number and why are they important?
- I see that the compound of interest is listed as the basic or acidic molecule, rather than the salt form. Does this make any difference in the calculation of the OEL/ADE?
- Is my drug is “cytotoxic?”
- What is an occupational exposure limit (OEL)?
- Once I have the ADE, what equation do I used to determine the MACO
- Can I obtain a copy of the CVs for the authors of the OEL Fastrac monographs?
- I want to learn to learn how to calculate ADEs myself?
- In the OEL and ADE equations, it appears that you didn’t use a weight factor of 50–70 kg.
- Is the use of a LD50 an acceptable point of departure?
- Can you add a short-term exposure limit (STEL) or ceiling limit to the monograph?
- What is does the term "point of departure" or PoD mean?
- We have an early stage compound; can we get an OEL Fastrac monograph developed for the compound?
- Do OEL Fastrac monographs include the maximum daily dose (MDD)?