I see that the compound of interest is listed as the basic or acidic molecule, rather than the salt form. Does this make any difference in the calculation of the OEL/ADE?

A large majority of all drug molecules used in medicinal therapy are administered as salts. Often, a drug substance has certain suboptimal physicochemical or biopharmaceutical properties that can be overcome by pairing a basic or acidic drug molecule with a counterion to create a salt version of the drug. Creating a salt version of the drug can improve solubility, stability, taste, manufacturability, and other key properties. In all but a few rare cases, the toxicology of the basic or acidic drug and the salt form are the same. 

Here at Affygility Solutions, when we are reviewing the scientific literature for a drug compound, the expert toxicologists are mindful of any differences. Unless otherwise indicated, the occupational exposure limit (OEL) and/or the acceptable daily exposure (ADE) for the basic or acidic drug molecule and the salt version of the drug would be the same.

Reference: Salt Selection in Drug Development (2008). PharmTech.com

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