What is an OEB 5 compound?

OEB 5 compounds are active pharmaceutical ingredients that have been assigned to an occupational exposure band (OEB) rating of 5, or the most severe rating in a 5-band occupational exposure banding system. A rating of OEB 5 represents those APIs that may have any of the following properties:

• Are highly potent (therapeutic doses less than 0.5 mg/day); or
• Have significant adverse effects at low doses (life-threatening, irreversible, or severe sensitizers); or
• May be genotoxic, carcinogenic, or have reproductive effects at relevant doses.

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